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INDIANAPOLIS, April 24, 2018 /PRNewswire/ - Eli Lilly and Company (NYSE: LLY) announced today results from a post-hoc subgroup analysis which demonstrated efficacy of galcanezumab in patients with episodic and chronic migraine who previously failed to respond to two or more preventive therapies. Detailed results from a new subgroup analysis of three Phase 3 studies (EVOLVE-1, EVOLVE-2 and REGAIN) evaluating galcanezumab will be presented today as part of the 'Best of Headache' platform session at the American Academy of Neurology (AAN) annual meeting in Los Angeles. As previously reported, in these Phase 3 studies, the most commonly-reported adverse events were injection site reactions. Food and Drug Administration ( FDA) is reviewing galcanezumab for the prevention of migraine in adults.
A decision is expected in the third quarter of 2018. 'Despite available options, research has shown nearly half of patients with migraine discontinue a newly-prescribed preventive therapy within sixty days of prescription, often due to side effects or lack of efficacy,' said Christi Shaw, president of Lilly Bio-Medicines.
'The research presented today on galcanezumab validates Lilly's decades-long effort to bring a new therapy to market that has the potential to help people experience more migraine-free days, regardless of past preventive therapy use.' Analysis Design EVOLVE-1, EVOLVE-2 and REGAIN were Phase 3, randomized, double-blind, placebo-controlled studies that evaluated the efficacy of two doses of galcanezumab (120 mg and 240 mg) in patients with episodic or chronic migraine. This subgroup analysis evaluated patients treated in the EVOLVE-1 and EVOLVE-2 studies for six months and the REGAIN study for three months. The subgroup analysis reviewed the mean change from baseline in the number of monthly migraine headache days and the proportion of patients with at least a 50 percent reduction in number of monthly migraine headache days in patients who previously failed two or more preventive therapies, using integrated EVOLVE-1 and EVOLVE-2 results and REGAIN results. Analysis Results In this subgroup analysis, patients treated with both doses of galcanezumab who previously failed two or more preventive therapies experienced a statistically significant reduction in the average number of monthly migraine headache days, and at least a 50 percent reduction in the number of migraine headache days, compared to patients treated with placebo. EVOLVE-1/ EVOLVE-2 (as evaluated over six months) for patients who failed at least 2 prior preventive medications (N=172):. Average reduction in monthly migraine headache days: 3.45 days for 120 mg and 3.85 days for 240 mg compared to 0.81 days for placebo, p.
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